Treatment is advised inside the administration of paracetamol to patients with serious renal or extreme hepatic impairment.
Cough medicines containing dihydrocodeine are controlled in the same way to dextromethorphan in the United States, in that its sale is strictly constrained by buy amount and is particularly limited to individuals 20 and more mature for acquire.
Headaches Make confident you rest and drink a lot of fluids. It could be ideal not to drink alcohol even though using dihydrocodeine as This may make headaches worse. It really is safe to take a painkiller like paracetamol or ibuprofen.
Dihydrocodeine is metabolized through CYP2D6 into the active metabolite, dihydromorphine, which contains a potency similar to morphine.
If you have been instructed by your physician that you simply have an intolerance to some sugars, Get hold of your health practitioner just before taking this medicinal product.
Get unexpected emergency medical help if you have indications of an allergic reaction: hives; tough breathing; swelling of your respective face, lips, tongue, or throat.
Patients ought to be closely monitored for indications of misuse, abuse, or addiction. The medical need to have for analgesic treatment need to be reviewed regularly.
Using this medicine when you are Expecting, In particular during the later Section of pregnancy may perhaps bring about severe undesired effects, together with neonatal withdrawal syndrome as part of your new child baby. Tell your medical professional without delay if you believe you are Expecting or if you propose to become pregnant though working with this medicine. Call your physician without delay if you have worsening of pain, elevated sensitivity to pain, or new pain immediately after having this medicine. These might be symptoms of opioid-induced hyperalgesia and allodynia. Check with your doctor instantly in case you or your child have panic, restlessness, a quick heartbeat, fever, sweating, muscle mass spasms, twitching, nausea, vomiting, diarrhea, or see or hear factors that are not there. These may very well be symptoms of a serious affliction called serotonin syndrome. Your hazard could possibly be higher should you also take particular other medicines that affect serotonin ranges in Your whole body. Employing far too much of the medicine might result in decreased infertility (struggling to have kids) or may well trigger a delay in ovulation for Gals and should affect their power to have children. Discuss with your medical professional right before utilizing this medicine if you plan to have little ones. Never take other medicines unless they have been discussed with your health care provider. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Side Effects
Drug withdrawal syndrome Prior to commencing treatment with any opioids, a discussion should be held with patients to put in place a withdrawal technique for ending treatment with dihydrocodeine.
Warning needs to be taken when paracetamol is utilised concomitantly with flucloxacillin as concurrent intake has been related with high anion gap metabolic acidosis, especially in patients with risks variables (see section 4.4).
Supplemental aid and checking can be important when prescribing for patients liable to opioid misuse.
Get medical help at once in the event you have any really critical side effects, which include: fainting, seizure.
AA. Characterization in the human cytochrome P450 enzymes involved in the metabolism of dihydrocodeine.
are allergic to dihydrocodeine or any with here the other ingredients of this medicine (listed in section 6)